Tips to open MOL file

Can't open the MOL file? You are not the only one. Thousands of users face similar problems every day. Below you will find tips on how to open MOL files as well as a list of programs that support MOL files.

MOL file extension

File Name MDL Molfile
File Developer Symyx Technologies
File Category Data Files

The MOL file is supported on 3 operating systems. Depending on your operating system, you may need different software to handle the MOL files. Below is a summary of the number of programs that support and open the MOL file on each system platform.

Operating systems
  • 3
  • 1
  • 1
  • 0
  • 0
  • 0

What is MOL file?

The MOL file has been categorized as Data Files. It was designed by Symyx Technologies. In addition to this file, the Data Files category includes 1326 related files. MDL Molfile is most often found on 3 operating systems. Although it can be found with greater or lesser success on any operating system, it will only be useful on Linux, Mac OS, Windows. There are also 4 alternative programs to handle the MOL file. HyperChem, Sybyl will apply when it is not possible to use Avogadro.

How to open MOL file?

The main problem with MDL Molfile is that the MOL file is incorrectly associated with programs. Thus, when you open MOL, the program selection wizard or some other program starts. This can be quickly resolved by following the instructions below.

The first thing you should do is just "doubleclick" on the MOL file icon you want to open. If the operating system has an appropriate application to support it and there is also an association between the file and the program, the file should be opened.

Step 1. Install Avogadro

In this case, you should first verify that the Avogadro application is installed on the computer. This can be achieved by typing Avogadro into the operating system search engine. In the absence of an appropriate program, its installation in the vast majority of cases will fix the problem. Below is a list of programs that support the file MOL.

Programs to open MOL file

Remember to download programs supporting MOL files only from verified and safe sources. We suggest using the websites of software developers.

Step 2. Create association of Avogadro with MOL files

If the application is or has been freshly installed, but the MOL file still does not use the Avogadro program, it means no association. The association can be created using the drop-down list available by right-clicking on the file and selecting Properties. The displayed window will contain information about the program that supports this type of file. Changes can be made using the "Change" button. It may happen that in the next window there will be no appropriate program - however, this can be corrected with the "Browse" option where you should manually indicate the program location. Checking the "Always use the selected program ..." box will permanently associate the MOL file with the Avogadro program.

Step 3. Update Avogadro to the latest version

The fault may also lie with the Avogadro program, it is possible that MDL Molfile requires a newer version of the program.

Step 4. Check for the following problems with the MOL file

If the above steps do not help, you can assume that the file itself is not correct. This could be due to the file itself, the cleanest issues are:

The affected file may be 0 KB or smaller than expected. This is most often caused by a problem while downloading the MOL file. The only repair option is to download the file again.
The computer may have fallen victim to a computer virus or hacker. A quick virus scan using an up-to-date antivirus program should clear up any doubts. Alternatively, you can use the scanners available online. The scan should cover the entire computer, not only the MOL file that we want to open. As a result of the scan, sometimes it is not possible to recover MOL files, which are deleted if there is a backup of this file, then after restoring it, it must also be scanned.
Older version of MOL file may not always be supported by the latest software version. Help should be sought from the software developer, as they usually recommend using free file converters or installing an older version of the program.
There can be many reasons for this. Depending on the type of file, it is necessary to repair it accordingly. Sometimes the program itself has options to repair the most popular MOL file corruption.
The program indicates that the file is encrypted or corrupted. The encrypted file MOL except for the special designation, works normally, but only on the device where it was encrypted, before transferring it to another machine, decryption is required.
Some operating systems do not allow file operations in certain locations, eg in system directories or directly on the system drive. While there is usually no problem reading such a file, it may not be possible to save it. It is best to move MOL to a different directory.
This can happen on a file that does not support multiple access. You may find that another program you are using is preventing you from working with the file. Just close unnecessary programs. Sometimes you have to wait for the session to the file MOL to close. Antivirus programs or a backup being made may lock the file for a while without the user's knowledge. If nothing helps, please reset the device.