Tips to open ML2 file

Can't open the ML2 file? You are not the only one. Thousands of users face similar problems every day. Below you will find tips on how to open ML2 files as well as a list of programs that support ML2 files.

ML2 file extension

File Name Tripos MOL2 Molecule
File Developer Hypercube, Inc.
File Category Misc Files

The ML2 file is supported on 1 operating systems. Depending on your operating system, you may need different software to handle the ML2 files. Below is a summary of the number of programs that support and open the ML2 file on each system platform.

Operating systems
  • 1
  • 0
  • 0
  • 0
  • 0
  • 0

What is ML2 file?

The file with the extension ML2 is the Misc Files file type. The author of this format is Hypercube, Inc.. Additionally, the Misc Files category contains 6033 of other files. Tripos MOL2 Molecule is most often found on 1 operating systems. These systems consist of Windows, although it may occasionally be found on another system, it will be non-functional. The main program that supports this format is HyperChem. This was created by Hypercube, Inc..

How to open ML2 file?

An often recurring problem with Tripos MOL2 Molecule is that ML2 is not associated with the correct program file. Thus, when you open ML2, the program selection wizard or some other program starts. This can be quickly resolved by following the instructions below.

The first thing you should do is just "doubleclick" on the ML2 file icon you want to open. If the operating system has an appropriate application to support it and there is also an association between the file and the program, the file should be opened.

Step 1. Install HyperChem

An often overlooked issue is to make sure that HyperChem is installed on the computer. This can be achieved by typing HyperChem into the operating system search engine. If it is not, installation may solve the problem, as most applications create file associations during installation. Below you will find a list of applications that support ML2 files.

Programs to open ML2 file

Remember to download programs supporting ML2 files only from verified and safe sources. We suggest using the websites of software developers.

Step 2. Create association of HyperChem with ML2 files

However, it may happen that the application itself does not cause the ML2 file to open in the HyperChem application, but you can set it manually. This option is available from the level of Properties of a specific file available in the context menu. The displayed window will contain information about the program that supports this type of file. Using the "Change" button we can set the program to handle this type. If there is no software on the list, simply select "Browse" and manually select the directory where the application is installed. The "always use the selected program ..." field will set the HyperChem application as the default for handling the ML2 file.

Step 3. Update HyperChem to the latest version

The fault may also lie with the HyperChem program, it is possible that Tripos MOL2 Molecule requires a newer version of the program. This can be done using the application (if it provides such options) or from the Hypercube, Inc. website and install the latest version.

Step 4. Check for the following problems with the ML2 file

If the above steps do not help, you can assume that the file itself is not correct. File problems can be divided into the following:

Very often, the file may be size 0 or incomplete. This suggests truncating the ML2 file contents when downloading or copying. Downloading the file again should fix the problem.
The operating system may be infected with a computer virus. A quick virus scan using an up-to-date antivirus program should clear up any doubts. Alternatively, you can use the scanners available online. The scan should cover the entire computer, not only the ML2 file that we want to open. Sometimes virus-infected ML2 files cannot be recovered, so make a backup in advance.
Older version of ML2 file may not always be supported by the latest software version. These problems are known and are often very easy to fix using the software developers's website.
There can be many reasons for this. Repairing is very dependent on the file type. Some programs offer the ability to automatically repair ML2 file corruption. The easiest way is to restore the file from a backup, if there is one, or contact Hypercube, Inc.
The program can also signal the fact of encryption. The encrypted ML2 files can be used by the device on which they were encrypted, on any other device it is required to have the appropriate cryptographic key and decrypt the file before its recovery.
Some operating systems do not allow file operations in certain locations, eg in system directories or directly on the system drive. While there is usually no problem reading such a file, it may not be possible to save it. If possible, you can try to move the ML2 file to another location.
This can happen on a file that does not support multiple access. You may find that another program you are using is preventing you from working with the file. Running programs (including those in the background) should be verified. Sometimes it is necessary to wait a while before referencing the ML2 file again. Some anti-virus or backup software may occupy the ML2 file for a certain period of time. If this does not work either, restart the device.